[The modern methods for the rehabilitation of adolescents suffering obesity]. / Sovremennye tekhnologii reabilitatsii podrostkov s ozhireniem.

BACKGROUND: To-day, obesity spreads dramatically fast all over the world not only among the adults but also among the children. According to the data available from the scientific literature, the number of adolescents suffering from obesity in Russia increased more than 1.5 times during the period from 2006 till 2015. The combination of non-drug therapeutic measures (including diet therapy, therapeutic physical exercises, and psychophysiological technologies) constitutes the basis for the treatment of obesity. Russia has gained a vast experience with the management of this condition with the use of natural and preformed therapeutic agents. AIM: The main objective of the present study was the comparative assessment of the effectiveness of the rehabilitation programs for the obese subjects with based on the application of alternative and complementary therapeutic modalities for the treatment of the adolescent girls with obesity. MATERIAL AND METHODS: The study included 86 girls with obesity at the age of 13-17 years who were randomly divided into 3 groups matched for the age and anthropometric characteristics. All the patients were prescribed a treatment course, including motivational training and aerobic exercise, in addition to the routine recommendations for the short-term modification of eating habits. The vacuum therapy was additionally included in the combined treatment protocol for the patients of the first group (n=28) while the patients of the second group (n=29) received the treatment in the spa capsule (SC) and the girls of the third group (n=29) underwent transcranial magnetic stimulation therapy. RESULTS: The analysis of the results obtained in this study has demonstrated a significant reduction of the body weight, waist and hip circumferences in the patients of all study groups (p<0.05). The comparison of these results with the baseline characteristics showed that the use of combined physiotherapy including the treatment in the spa capsule had significant advantages over local vacuum therapy in terms of weight dynamics (p=0.009), body mass index (p=0.009), hip circumference (p=0.019) and the chest skinfold thickness (p=0.02). CONCLUSION: The use of alternative and complementary therapeutic modalities in the combination with motivational training and aerobic exercises effectively contributes to the weight loss in the obese adolescent girls, with the combined pysiotherapeutic treatment having advantages over local therapy methods.

[The experience with the application of the selective electro-stimulation impacts in the children presenting with the disturbances of the locomotor function].

AIM: The objective of the present study was the improvement of the effectiveness of medical rehabilitation of the children presenting with the disturbances of the locomotor function using a «LymphaVision¼ apparatus for the selective electrical stimulation. MATERIALS AND METHODS: The study included 42 patients with movement disorders divided into two groups depending on the method of non-drug therapy. The main group was comprised of the patients receiving the treatment by electrical stimulation with the use of the «LymphaVision¼ apparatus while the remaining patients made up the group of comparison (they were treated with by means of Vermel electrophoresis with the use of a 1% sodium bromide solution). The increase of the muscular strength evaluated based on the scoring system and the number of motor skills were used as the criteria of the effectiveness of the treatment. The applied Statistica for Windows package, version 6.0 («StatSoft¼, USA). Was employed for the statistical analysis of the data obtained. The significance and number of differences between two independent samples of the quantitative features were assessed using the Mann-Whitney U test. The Wilcoxon matched pairs test was used to compare the two matched groups. RESULTS: The children comprising the group treated by means of selective exposure to electrical stimulation with the use of the «LymphaVision¼ apparatus in the course of the rehabilitation process exhibited a significant increase in the strength of the muscles of the lower extremities and the trunk over the baseline values (p=0.003 and p=0.04 respectively) and acquired a significantly greater number of the new motor skills (p=0.02). CONCLUSION: The application of the proposed method is characterized by the highly pronounced clinical efficiency. This approach is pathogenetically well-substantiated for the treatment of the children presenting with the locomotor disorders developing as the consequences of perinatal lesions in the central nervous system and promotes the restoration of the capabilities of the child's body, such as normalization of the muscle tone, increase of the motor activity and muscle strength.

[Gender differences in parameters of lipid metabolism and of level of antioxidants in groups of juveniles--the Evenks and the europeans].

Comparative estimation of the mean parameters of lipid metabolism and of level of antioxidants was performed in youths and girls of the indigenous (the Evenks) and newly arrived population of the north of the Irkutsk oblast and of the Oblast Center (the Europeans). Gender differences were revealed in the level of ChlHDLP in juveniles of the arrived population, in the glutathione status and content of fat-soluble vitamins in juveniles Evens and the arrived and in concentration of retinol in the Oblast Center juveniles. Adaptive changes in the AOD system were found in the Evenk girls (the higher concentrations of α-to- copherol, GSH, the GSH/GSSG index, and a decrease of GSSG relatively to the Evenk boys and the girls of the arrived populations, as well as an increase of the ca-tocopherol level relatively to the Europeans of the Oblast Center) and in boys of the arrived population (the higher GSH content and the GSH/GSSG index relatively to the Evenk boys).

[Importance of beta-glucuronidase activity and glycosaminoglycan concentration in synovial fluid in patients with rheumatoid arthritis in estimating local inflammation]. / Znachenie aktivnosti beta-gliucuronidazy i kontsentratsii glikozaminoglikanov v sinovial'noi zhidkosti u bol'nykh revmatoidnym artritom v otsenke mestnoi vospalitel'noi aktivnosti.

In 30 patients with rheumatoid arthritis, the activity of beta-glucuronidase and the content of sulfated and non-sulfated glycosaminoglycans (GAG) were measured in synovial fluid (SF) and in the cells of SF. It has been established that as the local inflammation increases, the activity of the enzyme and the content of sulfated GAG in SF also rise. This is accompanied by simultaneous reduction of beta-glucuronidase activity in the cells and by the drop of the hyaluronic acid content in SF.

[Glycosaminoglycans and beta-glucuronidase in peripheral blood cells and biological fluids of patients with rheumatoid arthritis]. / Glikozaminoglikany i beta-gliukuronidaza kletok perifericheskoi krovi i biologicheskikh zhidkostei pri revmatoidnom artrite.

Content of glycosaminoglycans and beta-glucuronidase activity were measured in leukocytes, blood serum and urine of patients with rheumatoid arthritis. Concentration of glycosaminoglycans was increased in blood serum and urine of the patients. The most distinct increase as compared with healthy persons in content of these substances was found in leukocytes of the patients with joint form of rheumatoid arthritis. Activity of beta-glucuronidase was also elevated in cells of peripheral blood, whereas content of protein was decreased in these cells. The enzymatic activity was reduced in the fraction of polymorphonuclear leukocytes of the patients as shown by estimation of the activity per 10(6) cells after fractionation using the Ficoll-verografin procedure. Deficiency of beta-glucuronidase activity in polymorphonuclear leukocytes appears to be among the factors responsible for excess of glycosaminoglycans in blood serum and urine of the patients as well as for chronic inflammation under conditions of rheumatoid arthritis.

[Clinical value of determining beta-glucuronidase and glycosaminoglycans in blood cells and biological fluids in patients with rheumatoid arthritis]. / Klinicheskoe znachenie opredeleniia beta-gliukuronidazy i glikozaminoglikanov v kletkakh krovi i biologicheskikh zhidkostiakh u bol'nykh revmatoidnym artritom.

Patients with proved rheumatoid arthritis (RA) demonstrated changes in the activity of beta-glucuronidase and the concentration of glycosaminoglycans (GAG) in the blood formed elements and biological fluids showing correlation with peculiarities of the RA course. The content of beta-glucuronidase and GAG in biological fluids well reflected the activity of an inflammatory process. Significant differences in the level of beta-glucuronidase and GAG in blood cells of patients with the articular type of RA and systemic manifestations of disease were revealed.